It is more common in males with an age peak at the fourth decade of life 2. Some tumors are true neoplasms, while some are hamartomas developmental malformations. Ghost cell odontogenic carcinoma arising from calcifying. Odontogenic carcinoma arising from benign odontogenic.
The 2005 who histological classification of odontogenic tumors lays out a classification system for neoplasms and other tumors related to the odontogenic apparatus. We report a case of a 70 yearold woman with a rapid onset of painful swelling right maxillary tumor. Calcifying ghost cell odontogenic cyst is comparatively rare in occurrence, constituting about 0. We report herein a case of a ghost cell odontogenic carcinoma arising in the mandible of a caucasian male 86 years of age. Other less common odontogenic malignant tumors include ghost cell odontogenic carcinoma and primary intraosseous squamous cell carcinomas 1, 16. The odontogenic ghost cell carcinoma ogcc is the malignant counterpart of a calcifying cystic odontogenic tumor and dentinogenic ghost cell tumor. Odontogenic and non odontogenic tumors of the jaws are a relatively rare and heterogeneous group of benign and malignant neoplasms, hamartomas, and other bonerelated lesions that demonstrate great variability in etiology, biologic behavior, and clinical significance. Ghost cell odontogenic carcinoma is an extremely rare odontogenic tumor with unclear etiology. Morgan odontogenic tumors comprise a range of disorders of growth, from malignant and benign. The chart showing pdf series, word series, html series, scan qr codes.
Squamous cell carcinoma scc in a survey of dogs with oropharyngeal tumors, scc was the second most frequently diagnosed oral tumor 24. Ghost cell odontogenic carcinoma gcoc is the malignant counterpart of calcifying cystic odontogenic tumour and dentinogenic ghost cell tumour. Odontogenic ghost cell carcinoma ogcc is a rare odontogenic tumor characterized by the presence of ghost cells. An odontogenic keratocyst is a rare and benign but locally aggressive developmental cyst. Calcifying cystic odontogenic tumor a case report and. Background clear cell odontogenic carcinoma ccoc, which has been described within the past 2 decades, is a rare odontogenic tumor that tends to occur in the mandible of older adults, with a predilection for women. Odontogenic cysts can give rise to a variety of neoplasms. On the basis of 52 examples of calcifying odontogenic cysts associated. Maxillary clear cell odontogenic carcinoma a rare entity. Dentinogenic ghost cell tumor odontogenic ectomesenchymal odontogenic. The most notable features of this pathologic entity are histopathological features which include a cystic lining demonstrating characteristic. Chapter 21 odontogenic and nonodontogenic tumors of the jaws introduction. Odontogenic ghost cell carcinoma ogcc, a malignant counterpart of the calcifying odontogenic cyst coc, is exceedingly rare. Ameloblastoma is a neoplasm of odontogenic epithelium, especially of enamel organtype tissue that has not undergone differentiation to the point of hard tissue formation.
Explanations and recommendations of the guidelines from the international collaboration on cancer reporting. This is the case of a middleaged male who presented with a slowgrowing maxillary tumour. Ameloblastoma, a type of odontogenic tumor involving ameloblasts. Pdf ghost cell odontogenic carcinoma is a rare condition characterized by ameloblasticlike islands of epithelial cells with aberrant. Calcifying epithelial odontogenic tumor of the maxilla. A 70yearold woman presented with a large painful radiolucent mandibular lesion from the right canine to the left angle area through the midline. Data set for the reporting of malignant odontogenic tumors. A,axial unenhanced ct scan shows a large, poorly marginated, lobulated softtissue mass causing irregular destruction of the body of the mandible, predominantly in the right. An odontogenic tumor is a neoplasm of the cells or tissues that initiate odontogenic processes examples include. There are previous reports of ameloblastic carcinoma misdiagnosed as ameloblastoma and treated more conservatively, leading to poor treatment outcome.
Pdf background the aim of this study was to integrate the available data published on calcifying odontogenic cyst coc, dentinogenic ghost cell tumor. It generally occurs in bone, and it has been postulated that the epithelium of origin is derived from one of the following sources. Although potentially locally destructive, okc is a benign odontogenic process that typically presents with clinical and radiographic features characteristic of a benign intraosseous neoplasm. Calcifying cystic odontogenic tumor ccot is defined as an odontogenic cyst like benign neoplasm that characteristically contains several. Clinicopathological analysis of histological variants of. Ghost cell odontogenic carcinoma gcoc is a rare malignant. Ghost cell odontogenic carcinoma is a rare condition characterized by. This book greatly expands the body of knowledge in the field of odontogenic tumor pathology. Odontogenic tumors questions and study guide quizlet. Ameloblastic carcinoma, calcifying odontogenic cyst, ghost cell carcinoma, keratinizing epithelial odontogenic cyst, maxillary tumor, odontogenic carcinoma. Clear cell odontogenic tumora new histologic variant with aggressive potential. Multiple basal cell carcinomas multiple jaw cysts odontogenic keratocysts numerous bone abnormalities including bi.
Clear cell odontogenic carcinoma mimicking a cystic lesion. Ledesmamontes c, gorlin rj, shear m, praetorius f, et al. Ghost cell odontogenic carcinoma gcoc is a rare malignant odontogenic epithelial tumor with features of benign calcifying odontogenic cysts. Ghost cell odontogenic carcinoma, aggressive epithelial ghost cell odontogenic tumor, dentinogenic ghost cell ameloblastoma, carcinoma arising in a coc, and malignant calcifying ghost cell odontogenic tumor 6. Chapter 21 odontogenic and non odontogenic tumors of the jaws introduction. Although known by many names, the basic histologic identifying feature includes the identification of the ghost cells and the malignant changes associated with the cells. Until now, only 31 cases of ogccs have been reported in literature. Ghost cell odontogenic carcinoma gcoc is a rare malignant variant of odontogenic tumor with ghost cells.
It most often affects the posterior mandible and most commonly presents in the third decade of life. Mandibular clear cell odontogenic carcinoma world journal. Case report mandibular ghost cell odontogenic carcinoma. Avila, md2 1department of pathology philippine general hospital university of the philippines manila 2department of pathology college of medicine philippine general hospital university of the philippines manila.
We have described the clinical and radiographic features, histological. Ki67 and p53 expression in ghost cell odontogenic carcinoma. The present report describes 2 cases of primary intraosseous squamous cell carcinoma. Odontogenic ghost cell carcinoma with pulmonary metastasis.
Dentigerous cysts are one of the most common odontogenic cysts of the oral cavity. In two surveys of oropharyngeal tumors in cats the most frequently diagnosed tumor was scc, representing 6164% of the oral tumors. International collaborative study on ghost cell odontogenic tumours. Odontogenic and nonodontogenic tumors of the jaws are a relatively rare and heterogeneous group of benign and malignant neoplasms, hamartomas, and other bonerelated lesions that demonstrate great variability in etiology, biologic behavior, and clinical significance. Previous descriptions of this tumor were based on identification of malignant histologic characteristics such as infiltration, cellular pleomorphism, numerous mitoses, and necrosis concurrent with classical benign coc or its solid benign variant, the. It is a potentially aggressive tumour, capable of recurring frequently, locally invasive, and with distant metastases. Ghost cell odontogenic carcinoma arising in the background of a. Clear cell odontogenic carcinoma ccoc is a rare odontogenic tumor with predominance in the posterior mandible, usually occurring in the fifth to seventh decades of life, and being found more commonly in females. Odontogenic tumor article about odontogenic tumor by the. There have been very few reports about gcocs arising from. It describes the epidemiologic, radiologic, and histopathologic features of presently known neoplasms and hamartomatous or tumorlike lesions arising from the toothforming structures, as well as a number of distinctive jaw lesions that must be distinguished from odontogenic. We describe a case of gcoc which was considerably derived from a previously resected calcifying cystic odontogenic tumor ccot. Primary malignant tumors of the jaws can arise from odontogenic epithelial remnants within the alveolar segment or from the transformation or degeneration of benign lesions. Clear cell odontogenic tumor is a rare neoplasm of the jaws that histologically may be confused with metastatic renal cell carcinoma.
Previous descriptions of this tumor were based on identification of malignant histologic characteristics such as infiltration, cellular pleomorphism, numerous mitoses, and necrosis concurrent with classical benign coc or its solid benign. Aggressive epithelial odontogenic ghost cell tumor in the. Pdf calcifying odontogenic cyst, dentinogenic ghost cell tumor. Ghost cell odontogenic carcinoma gcoc is a rare malignant odontogenic tumor, only 37 cases of gcoc have been reported in the. Odontogenic carcinoma is rare group of malignant epithelial odontogenic neoplasms with characteristic clinical behavior and histological features, which requires an aggressive surgical approach. Odontogenic ghost cell carcinoma ogcc is a rare neoplastic variant of calcifying odontogenic cyst, with aggressive clinical characteristics. Clear cell odontogenic carcinoma ccoc, clear cell odontogenic tumor previously called clear cell ameloblastoma considered benign by who of 1992, but due to its high potential for regional spread and distant metastases, it was reclassified as malignant in 2005. Ghost cell odontogenic carcinoma arising in the background of a benign calcifying cystic odontogenic tumor of the mandible. The sqamous cell carcinoma should also be considered because of cytological pleomorphism and intercellular bridges2.
Primary intraosseous squamous cell carcinoma arising in. Martosfernandez m, alberolaferranti m, huetomadrid ja, bescosatin c. Calcifying ghost cell odontogenic tumor cgcot with. The clear cell variant of ceot can be mistaken for clear cell odontogenic carcinoma, some metastatic carcinoma, like renal cell carcinoma, and some salivary gland tumors like mucoepidermoid carcinoma and acinic cell carcinoma2. Odontogenic keratocysts make up around 19% of jaw cysts. Clear cell odontogenic carcinoma ccoc is a rare intraosseous carcinoma of the jaw. Ghost cell odontogenic carcinoma gcoc was first described in detail as a malignant focus within a calcifying odontogenic cyst coc by ikemura et al. Johnson et al reported the occurrence of 60% of the tumors in mandible, 30% in the form of peripheral calcifying odontogenic cysts and anterior part of the jaw was involved in 53% of cases9. At the time of writing 2016, it is still the most widely used classification system although a new revision is due to come up in 2017. Nevoid basal cell carcinoma syndrome gorlin goltz syndrome ccot calcifying cystic odontogenic tumor derived from odontogenic epithelial cell rest. In the whoiarc classification of head and neck pathology, this clinical entity had been known for years as the odontogenic. Odontogenic tumors comprise a complex group of lesions with varied histopathological and clinical features.
Feedback controls limit cell division after a certain number of cells have developed, allowing for tissue repair click the link for more information. The calcifying ghost cell odontogenic cyst cgcoc was first described by gorlin et al. Squamous cell carcinoma arising within a maxillary. Clear cell odontogenic carcinoma ghost cell odontogenic carcinoma odontogenic sarcomas ameloblastic. Ghost cell odontogenic carcinoma is a rare condition characterized by ameloblasticlike islands of epithelial cells with aberrant keratinitation in the form of ghost cell with varying amounts of dysplastic dentina. The pathogenesis of this rare group remains still controversial and there have been many varied opinions over the classification of this rare group of lesions. Consequently, the name clear cell odontogenic carcinoma was thought to be more appropriate in view of the malignant potential manifested by this neoplastic lesion 2022. Ghost cell odontogenic carcinoma on right mandible and its. Odontogenesis, odontogenic cysts, and odontogenic tumors. In 1992 who published the second edition of histological typing of odontogenic tumors. Odontogenic carcinoma arising from benign odontogenic cysts. Calcifying ghost cell odontogenic tumor cgcot was first described by gorlin et al. Gorlin nevoid basal cell carcinoma syndrome basal cell carcinomas in nonsun exposed areas.
Squamous cell carcinoma scc arising within the lining of an odontogenic keratocyst okc is a rare occurrence. D, frcpath assistant prof of general pathology senior lecturer of oral pathology and oral histology slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Pathogenesis and nomenclature of odontogenic carcinomas. Some are composed only of odontogenic epithelium, while many are mixed i. Ghost cell odontogenic carcinoma med oral patol oral cir bucal. Odontogenic ghost cell carcinoma johns hopkins university. Lim, md1, odontogenic ghost cell carcinoma of the maxilla jose m. Ghost cell odontogenic carcinoma gcoc is an exceptionally rare and malignant odontogenic tumor with aggressive growth characteristics. The distinct feature of this lesion is a cystic lining demonstrating ghost epithelial cells with a.